Search | Virtual Health Library

1.

A Photoaffinity-Based Fragment-Screening Platform for Efficient Identification of Protein Ligands.

Grant, Emma K; Fallon, David J; Hann, Michael M; Fantom, Ken G M; Quinn, Chad; Zappacosta, Francesca; Annan, Roland S; Chung, Chun-Wa; Bamborough, Paul; Dixon, David P; Stacey, Peter; House, David; Patel, Vipulkumar K; Tomkinson, Nicholas C O; Bush, Jacob T.

Angew Chem Int Ed Engl ; 59(47): 21096-21105, 2020 11 16.

Article in English | MEDLINE | ID: mdl-32745361

2.

Glutathione transferases catalyze recycling of auto-toxic cyanogenic glucosides in sorghum.

Bjarnholt, Nanna; Neilson, Elizabeth H J; Crocoll, Christoph; Jørgensen, Kirsten; Motawia, Mohammed Saddik; Olsen, Carl Erik; Dixon, David P; Edwards, Robert; Møller, Birger Lindberg.

Plant J ; 94(6): 1109-1125, 2018 06.

Article in English | MEDLINE | ID: mdl-29659075

3.

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.

Virk, Bhupinder; Correia, Gonçalo; Dixon, David P; Feyst, Inna; Jia, Jie; Oberleitner, Nikolin; Briggs, Zoe; Hodge, Emily; Edwards, Robert; Ward, John; Gems, David; Weinkove, David.

BMC Biol ; 10: 67, 2012 Jul 31.

Article in English | MEDLINE | ID: mdl-22849329

4.

Xenobiotic responsiveness of Arabidopsis thaliana to a chemical series derived from a herbicide safener.

Skipsey, Mark; Knight, Kathryn M; Brazier-Hicks, Melissa; Dixon, David P; Steel, Patrick G; Edwards, Robert.

J Biol Chem ; 286(37): 32268-76, 2011 Sep 16.

Article in English | MEDLINE | ID: mdl-21778235

5.

The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands.

Dixon, David P; Sellars, Jonathan D; Edwards, Robert.

Biochem J ; 438(1): 63-70, 2011 Aug 15.

Article in English | MEDLINE | ID: mdl-21631432

6.

Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attachment.

Wensel, David; Williams, Shawn; Dixon, David P; Ward, Paris; McCormick, Patti; Concha, Nestor; Stewart, Eugene; Hong, Xuan; Mazzucco, Charles; Pal, Shreya; Ding, Bo; Fellinger, Christoph; Krystal, Mark.

J Mol Biol ; 434(2): 167395, 2022 01 30.

Article in English | MEDLINE | ID: mdl-34896364

7.

Roles for stress-inducible lambda glutathione transferases in flavonoid metabolism in plants as identified by ligand fishing.

Dixon, David P; Edwards, Robert.

J Biol Chem ; 285(47): 36322-9, 2010 Nov 19.

Article in English | MEDLINE | ID: mdl-20841361

8.

Multiple roles for plant glutathione transferases in xenobiotic detoxification.

Cummins, Ian; Dixon, David P; Freitag-Pohl, Stefanie; Skipsey, Mark; Edwards, Robert.

Drug Metab Rev ; 43(2): 266-80, 2011 May.

Article in English | MEDLINE | ID: mdl-21425939

9.

Fluorescence quenched quinone methide based activity probes--a cautionary tale.

Sellars, Jonathan D; Landrum, Marie; Congreve, Aileen; Dixon, David P; Mosely, Jackie A; Beeby, Andrew; Edwards, Robert; Steel, Patrick G.

Org Biomol Chem ; 8(7): 1610-8, 2010 Apr 07.

Article in English | MEDLINE | ID: mdl-20237672

10.

Getting the most out of publicly available T-DNA insertion lines.

Ulker, Bekir; Peiter, Edgar; Dixon, David P; Moffat, Caroline; Capper, Richard; Bouché, Nicolas; Edwards, Robert; Sanders, Dale; Knight, Heather; Knight, Marc R.

Plant J ; 56(4): 665-77, 2008 Nov.

Article in English | MEDLINE | ID: mdl-18644000

11.

Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily.

Dixon, David P; Hawkins, Timothy; Hussey, Patrick J; Edwards, Robert.

J Exp Bot ; 60(4): 1207-18, 2009.

Article in English | MEDLINE | ID: mdl-19174456

12.

An efficient method for 15N-labeling of chitin in fungi.

Watson, Helen R; Apperley, David C; Dixon, David P; Edwards, Robert; Hodgson, David R W.

Biomacromolecules ; 10(4): 793-7, 2009 Apr 13.

Article in English | MEDLINE | ID: mdl-19249848

13.

A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification.

Bamborough, Paul; Chung, Chun-Wa; Demont, Emmanuel H; Bridges, Angela M; Craggs, Peter D; Dixon, David P; Francis, Peter; Furze, Rebecca C; Grandi, Paola; Jones, Emma J; Karamshi, Bhumika; Locke, Kelly; Lucas, Simon C C; Michon, Anne-Marie; Mitchell, Darren J; Pogány, Peter; Prinjha, Rab K; Rau, Christina; Roa, Ana Maria; Roberts, Andrew D; Sheppard, Robert J; Watson, Robert J.

J Med Chem ; 62(16): 7506-7525, 2019 08 22.

Article in English | MEDLINE | ID: mdl-31398032

14.

Protein-Ligand Fishing in planta for Biologically Active Natural Products Using Glutathione Transferases.

Dixon, David P; Edwards, Robert.

Front Plant Sci ; 9: 1659, 2018.

Article in English | MEDLINE | ID: mdl-30510558

15.

Cloning and characterization of a theta class glutathione transferase from the potato pathogen Phytophthora infestans.

Bryant, David; Cummins, Ian; Dixon, David P; Edwards, Robert.

Phytochemistry ; 67(14): 1427-34, 2006 Jul.

Article in English | MEDLINE | ID: mdl-16797619

16.

Enzymes of tyrosine catabolism in Arabidopsis thaliana.

Dixon, David P; Edwards, Robert.

Plant Sci ; 171(3): 360-6, 2006 Sep.

Article in English | MEDLINE | ID: mdl-22980205

17.

Plant glutathione transferases.

Edwards, Robert; Dixon, David P.

Methods Enzymol ; 401: 169-86, 2005.

Article in English | MEDLINE | ID: mdl-16399386

18.

Differential induction of glutathione transferases and glucosyltransferases in wheat, maize and Arabidopsis thaliana by herbicide safeners.

Edwards, Robert; Del Buono, Daniele; Fordham, Michael; Skipsey, Mark; Brazier, Melissa; Dixon, David P; Cummings, Ian.

Z Naturforsch C J Biosci ; 60(3-4): 307-16, 2005.

Article in English | MEDLINE | ID: mdl-15948600

19.

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors.

Bamborough, Paul; Chung, Chun-wa; Furze, Rebecca C; Grandi, Paola; Michon, Anne-Marie; Sheppard, Robert J; Barnett, Heather; Diallo, Hawa; Dixon, David P; Douault, Clement; Jones, Emma J; Karamshi, Bhumika; Mitchell, Darren J; Prinjha, Rab K; Rau, Christina; Watson, Robert J; Werner, Thilo; Demont, Emmanuel H.

J Med Chem ; 58(15): 6151-78, 2015 Aug 13.

Article in English | MEDLINE | ID: mdl-26230603

20.

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors.

Demont, Emmanuel H; Chung, Chun-wa; Furze, Rebecca C; Grandi, Paola; Michon, Anne-Marie; Wellaway, Chris; Barrett, Nathalie; Bridges, Angela M; Craggs, Peter D; Diallo, Hawa; Dixon, David P; Douault, Clement; Emmons, Amanda J; Jones, Emma J; Karamshi, Bhumika V; Locke, Kelly; Mitchell, Darren J; Mouzon, Bernadette H; Prinjha, Rab K; Roberts, Andy D; Sheppard, Robert J; Watson, Robert J; Bamborough, Paul.

J Med Chem ; 58(14): 5649-73, 2015 Jul 23.

Article in English | MEDLINE | ID: mdl-26155854

Virtual Health Library

United States - Mexico Border

Your selection (0)

Export format:

Export:

A Photoaffinity-Based Fragment-Screening Platform for Efficient Identification of Protein Ligands.

Glutathione transferases catalyze recycling of auto-toxic cyanogenic glucosides in sorghum.

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.

Xenobiotic responsiveness of Arabidopsis thaliana to a chemical series derived from a herbicide safener.

The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands.

Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attachment.

Roles for stress-inducible lambda glutathione transferases in flavonoid metabolism in plants as identified by ligand fishing.

Multiple roles for plant glutathione transferases in xenobiotic detoxification.

Fluorescence quenched quinone methide based activity probes--a cautionary tale.

Getting the most out of publicly available T-DNA insertion lines.

Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily.

An efficient method for 15N-labeling of chitin in fungi.

A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification.

Protein-Ligand Fishing in planta for Biologically Active Natural Products Using Glutathione Transferases.

Cloning and characterization of a theta class glutathione transferase from the potato pathogen Phytophthora infestans.

Enzymes of tyrosine catabolism in Arabidopsis thaliana.

Plant glutathione transferases.

Differential induction of glutathione transferases and glucosyltransferases in wheat, maize and Arabidopsis thaliana by herbicide safeners.

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors.

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors.